University of Central Florida Undergraduate Research Journal - Anatomy and Function of Autonomic Innervation of the Liver
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Anatomy and Function of Autonomic Innervation
of the Liver

By: Kennan Negrete | Mentor: Dr. Zixi Cheng


The connection between the liver and the central nervous system is a vastly under-studied arena with various unknown structures, functions, and mechanisms (Akiyoshi et al., 1998; Berthoud, 2004; Kalsbeek et al., 2010; McCuskey, 2004; Perez-Tilve et al., 2010; Taher et al., 2017; Verma et al., 2018; Yi et al., 2010). A large part of this knowledge gap is due to the inability of previous technologies to properly isolate and map liver innervation (Berthoud, 2004; Yi et al., 2010). As biomedical sciences continue to advance and our understanding of the neural structure and function of the liver improves, these questions may be answered, thereby revealing more of the widespread impact of autonomic hepatic innervation in both normal physiology and disease states. Such an under-studied yet critically important organ provides an exciting frontier for continued research and the potential for intriguing new discoveries. This paper provides a brief analysis of past and current data, taking special note of areas that require a great deal of further study. Revisiting the issue of autonomic influence upon hepatic function could prove incredibly useful to both the scientific and medical community.

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